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2) Place the mixture in a sealable bag, empty can, or other container to prevent the drug from leaking or breaking out of a garbage bag, or to dispose of in accordance with local state guidelines and/or regulations.Call your healthcare provider or get emergency medical help right away if anyone taking Promethazine Hydrochloride and Codeine Phosphate Oral Solution, or your breastfeeding baby, has any of the symptoms below:Taking Promethazine Hydrochloride and Codeine Phosphate Oral Solution with certain other medicines can cause side effects or affect how well Promethazine Hydrochloride and Codeine Phosphate Oral Solution or the other medicines work. Monitor for respiratory depression, especially during initiation of Promethazine HCl and Codeine Phosphate Oral Solution therapy or when used in patients at higher risk [Accidental ingestion of even one dose of Promethazine HCl and Codeine Phosphate Oral Solution, especially by children, can result in a fatal overdose of codeine [Ultra-Rapid Metabolism of Codeine and Other Risk Factors for Life-Threatening Respiratory Depression in ChildrenLife-threatening respiratory depression and death have occurred in children who received codeine. Presentation of adrenal insufficiency may include non-specific symptoms and signs including nausea, vomiting, anorexia, fatigue, weakness, dizziness, and low blood pressure. The phosphate salt of codeine occurs as white, needle-shaped crystals or white crystalline powder. Only in exceptional medical cases may patients with organic brain damage or brain stem diseases such as Parkinson’s disease or Parkinson’s syndrome receive promethazine. Patients should not start MAOIs while taking Promethazine HCl and Codeine Phosphate Oral Solution [Inform patients that Promethazine HCl and Codeine Phosphate Oral Solution may cause orthostatic hypotension and syncope.
Advise patients to avoid concomitant use of Promethazine HCl and Codeine Phosphate Oral Solution with benzodiazepines or other CNS depressants and to not use alcohol while taking Promethazine HCl and Codeine Phosphate Oral Solution [Advise patients of the potential for severe constipation [Inform patients that anaphylaxis has been reported with ingredients contained in Promethazine HCl and Codeine Phosphate Oral Solution.
(Oral solution: Each 5 mL contains codeine phosphate, 10 mg and promethazine hydrochloride 6.25 mg, in a clear, purple red, peach-mint flavor syrup. Depression in Health care providers should be aware that addiction may not be accompanied by concurrent tolerance and symptoms of physical dependence in all addicts. Risks are increased in patients with a personal or family history of substance abuse (including drug or alcohol abuse or addiction) or mental illness (e.g., major depression).Opioids are sought by drug abusers and people with addiction disorders and are subject to criminal diversion. There is no general agreement about specific pharmacological treatment regimens for uncomplicated NMS.Since recurrences of NMS have been reported with phenothiazines, avoid use of Promethazine HCl and Codeine Phosphate Oral Solution in patients with a history consistent with NMS.Promethazine HCl and Codeine Phosphate Oral Solution contains promethazine, a phenothiazine. Avoid the use of Promethazine HCl and Codeine Phosphate Oral Solution in patients taking benzodiazepines, other CNS depressants, or alcohol. Concomitant administration with other respiratory depressants may increase the risk of respiratory depression. Morphine and its M6 glucuronide conjugate are pharmacologically active.
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