";s:4:"text";s:8060:"With clear indications that XDR tuberculosis results from mismanaged cases of drug-susceptible and MDR tuberculosis, it is imperative to treat drug-susceptible tuberculosis appropriately to completion, and to provide rapid diagnosis, and aggressive as well as appropriate treatment of MDR tuberculosis to avoid the unnecessary development of additional cases of XDR tuberculosis. 1: Erkens CGM, Kamphorst M, Abubakar I, et al. Enter multiple addresses on separate lines or separate them with commas. Sign In to Email Alerts with your Email Address, Recommended dosing frequency for standard 6-month regimen, Suggested antituberculosis retreatment regimens for previously treated patients, Dosages of antituberculosis drugs used in treatment of multidrug-resistant tuberculosis in adults, Surgical treatment of multidrug-resistant tuberculosis, Preliminary studies on adjunctive immunotherapy of multidrug-resistant tuberculosis, Grading of evidences for recommendations according to the Scottish Intercollegiate Guidelines Network, Global tuberculosis control: a short update to the 2009 report. WHO/HTM/TB/2009.426. Treatment of multidrug-resistant tuberculosis. Comparison of a four-drug fixed-dose combination regimen with a single tablet regimen in smear-positive pulmonary tuberculosis, Assessment of a combined preparation of isoniazid, rifampicin and pyrazinamide (Rifater®) in the initial phase of chemotherapy in three 6-month regimens for smear positive pulmonary tuberculosis: a five-year follow-up report, How drug resistance emerges as a result of poor compliance during short course chemotherapy for tuberculosis, The early bactericidal activities of rifampin and rifapentine in pulmonary tuberculosis, Early bactericidal activity of high-dose rifampin in patients with pulmonary tuberculosis evidenced by positive sputum smears, Tuberculosis pharmacotherapy: strategies to optimize patient care, An official ATS statement: hepatotoxicity of antituberculosis therapy, Toxic hepatitis with isoniazid and rifampin. A meta-analysis, Pharmacokinetics and tolerability of a higher rifampin dose, U.S. Public Health Service Cooperative Trial of three rifampin-isoniazid regimens in treatment of pulmonary tuberculosis, African Poverty Related Infection Oriented Research Initiative, Pharmacokinetics and pharmacodynamics of high, Rifapentine and isoniazid in the continuation phase of a 6-month regimen. The main priority interventions would be: 1) strengthening control of tuberculosis, through sound implementation of the Stop TB Strategy, with special focus on laboratory capacities and infection control (including HIV control); 2) improvement of programmatic management of drug-resistant tuberculosis, based on updated guidelines, largely from WHO; and 3) promotion of research and development of new diagnostics, vaccines and drugs, as well as other modalities of therapy. Comanagement of HIV and active TB disease, Treatment of extrapulmonary TB and of TB in special situations, Essential firstline antituberculosis drugs, Summary of evidence and considerations underlying the recommendations, Stop TB Initiative (World Health Organization). Treatment of tuberculosis by World Health Organization, 2010, World Health Organization edition, in English - 4th ed. Get this from a library! This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. Check out the new look and enjoy easier access to your favorite features, The World Health Organization's Stop TB Department has prepared this fourth edition of. Fluoroquinolones: are they essential to treat multidrug-resistant tuberculosis? Methods of Tuberculosis Screening Diagnosis of active or latent TB involves a number of tests. WHO/HTM/TB/2010.3. Prolonged survival with appropriate therapy, Outcome of chemotherapy in 107 patients with pulmonary tuberculosis resistant to isoniazid and rifampin, The treatment of multidrug-resistant tuberculosis in Turkey, A national study of clinical and laboratory factors affecting the survival of patients with multiple drug resistant tuberculosis in the UK, Community-based therapy for multidrug-resistant tuberculosis in Lima, Peru, Nosocomial transmission of multidrug-resistant, An outbreak of multidrug-resistant tuberculosis among hospitalized patients with the acquired immunodeficiency syndrome, Risk factors and mortality associated with default from multidrug-resistant tuberculosis treatment, Impact of extensive drug resistance on treatment outcomes in non-HIV-infected patients with multidrug-resistant tuberculosis, Multidrug-resistant tuberculosis treatment outcomes in Karakalpakstan, Uzbekistan: treatment complexity and XDR-TB among treatment failures, HIV co-infection in multidrug- and extensively drug-resistant tuberculosis results in high early mortality, Predictors of poor treatment outcome in multidrug- and extensively drug-resistant pulmonary TB, Treatment outcomes among patients with multidrug-resistant tuberculosis: systematic review and meta-analysis, Comprehensive treatment of extensively drug-resistant tuberculosis, Epidemiology and clinical management of XDR-TB: a systematic review by TBNET, New tuberculosis therapeutics: a growing pipeline, Moxifloxacin-containing regimen greatly reduces time to culture conversion in murine tuberculosis, Moxifloxacin-containing regimens of reduced duration produce a stable cure in murine tuberculosis, A Phase II study of the sterilizing activities of ofloxacin, gatifloxacin and moxifloxacin in pulmonary tuberculosis, Substitution of moxifloxacin for isoniazid during intensive phase treatment of pulmonary tuberculosis, Adding moxifloxacin is associated with a shorter time to culture conversion in pulmonary tuberculosis, Controlled comparison of two moxifloxacin containing treatment shortening regimens in pulmonary tuberculosis (REMox TB), Isoniazid or moxifloxacin in rifapentine-based regimens for experimental tuberculosis, Rifapentine plus moxifloxacin for treatment of pulmonary tuberculosis, Increasing incidence of fluoroquinolone-resistant, Early treatment outcomes of extensively drug-resistant tuberculosis in South Africa are poor regardless of HIV status, Multiplex PCR amplimer conformation analysis for rapid detection of, A diarylquinoline drug active on the ATP synthase of, Impact of the interaction of R207910 with rifampin on the treatment of tuberculosis studied in the mouse model, Synergistic activity of R207910 combined with pyrazinamide against murine tuberculosis, A once-weekly R207910-containing regimen exceeds activity of the standard daily regimen in murine tuberculosis, Combinations of R207910 with drugs used to treat multidrug-resistant tuberculosis have the potential to shorten treatment duration, Early bactericidal activity and pharmacokinetics of the diarylquinoline TMC-207 in treatment of pulmonary tuberculosis, TMC207-TiDP13-C208: anti-bacterial activity, safety, and tolerability of TMC207 in patients with multidrug-resistant, The diarylquinoline TMC207 for multidrug-resistant tuberculosis, OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis, Otsuka Pharmaceutical Development & Commercialization Inc, A placebo-controlled, phase 2 trial to evaluate OPC 67683 in patients with pulmonary sputum culture-positive, multidrug-resistant tuberculosis (TB), A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis, Bactericidal activity of the nitroimidazopyran PA-824 in a murine model of tuberculosis, Enhanced bactericidal activity of rifampin and/or pyrazinamide when combined with PA-824 in a murine model of tuberculosis, Powerful bactericidal and sterilizing activity of a regimen containing PA-824, moxifloxacin, and pyrazinamide in a murine model of tuberculosis, Safety, tolerability and pharmacokinetics of PA-824 in healthy subjects, Comparison of the sterilizing activities of the nitroimidazopyran PA-824 and moxifloxacin against persisting, Toward an optimized therapy for tuberculosis? 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