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Mol Biol Cell 4:413–424Kloppel G, Dreyer T, Willemer S, Kern H, Adler G (1986) Human acute pancreatitis: its pathogenesis in the light of immunocytochemical and ultrastructural findings in acinar cells.
***Arterial GasometryAs soon as possible, intensive care measures were established based on the continuous monitoring of cardiac and respiratory function. Vesicle-associated membrane protein (VAMP) cleavage by a new metalloprotease from the Brazilian scorpion Tityus serrulatus. Toxicon 12:509–511Corrado AP, Neto FR, Antonio A (1974) The mechanism of the hypertensive effect of Brazilian scorpion venom (Diniz CR (1971) Clinical and pharmacological properties of Fletcher PL Jr, Fletcher MD, Possani LD (1992) Characteristics of pancreatic exocrine secretion procuced by venom from the Brazilian scorpion Freire-Maia L, Azevedo AD, Costa Val VP (1973) Respiratory arrhythmias produced by purified scorpion toxin.
Although it is not common to find severe scorpion envenomations in adults, physicians should consider the risk of clinical complications if the patient has multiple comorbities.
Toxicon, 55(6):1125-1131, 07 Jan 2010 Cited by: 6 articles | PMID: 20060404
March 21, 2018; Accepted:
The present review deals with Ts venom and toxins studies and focuses on their effects on all anatomic systems.
We studied in vivo and in vitro morphological aspects of pancreatic acinar cells after treatment with Immediate online access to all issues from 2019. In the Northeast region of Brazil, Scorpion envenomation is reported in many parts of the world and is more frequent in tropical and subtropical countriesSince the early 2000s, the number of scorpion envenoming cases in Brazil have increased. Toxicon 11:255–257Freire-Maia L, Pinto GI, Franco I (1974) Mechanism of the cardiovascular effects produced by purified scorpion toxin in the rat. Tityus serrulatus: biology and epidemiology. In human envenomations caused by the Although scorpion venom causes an inflammatory reaction largely mediated by cytokines in the lungs, kidneys, heart and intestine of experimental ratsThere are very few cases reported about pancreatic involvement due to scorpion envenomationa Years old; b Not reported; c Minimum – maximum; d Increase in serum creatinine or decrease in its clearance by more than 50% of standard values was considered as renal failure; e- number of patients with described characteristic were represented between parenthesis; f- haemorrhagic pancreatitis, pseudocyst formations.The mainstay of pancreatitis pathogenesis due to scorpion sting is the cholinergic discharge induced by its toxinsSeveral laboratory abnormalities have been described in scorpion envenomation, including elevation of renal and pancreatic biomarkers, electrolytic disorders, hyperglycemia, coagulation disturbancesIn this case, AKI was associated to scorpionism. Fletcher PL, Fletcher MD, Weninger K, Anderson TE, Martin BM.
After the antivenom administration, the patient reported improvement of abdominal pain, while amylase and lipase returned to normal levels in a few days.Despite the abdominal symptoms improvement, the patient developed non-oliguric AKI, according the KDIGO criteriaThree months later, the patient returned with total recovery of renal and pancreatic functions, asymptomatic, with normal blood pressure (120 x 60 mmHg). J Biol Chem. Over the past three decades (since 1981), our research team has undertaken several studies involving the isolation, purification and characterization of toxins from the Brazilian yellow scorpion T. serrulatus (Ts). In: Ohsaka A, Hayashi K, Sawai Y (eds) Animal plant and microbial toxins, vol 2. Seven hours after the sting, she presented worsening of symptoms and received vigorous venous hydration and primary medical care.Upon admission, the patient presented a compromised general condition, lowered consciousness level (Glasgow Coma Scale Score of 11, in a scale from 3-15) and blood pressure was 150 x 110 mmHg. Ribeiro EL, Pinto MC, Labarrère CR, Paes PR, Paes-Leme FO, Chávez-Olórtegui C, Melo MM. Proc Natl Acad Sci USA 61:1123–1128Lampel M, Kern H (1977) Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue. Animal models of acute and chronic pancreatitis have been created to examine mechanisms of pathogenesis, test therapeutic interventions, and study the influence of inflammation on the development of pancreatic cancer.
Scorpion antivenom was administered (six vials intravenously), without anaphylactic symptoms. Gastroenterology 92:345–353Sofer S, Shalev H, Weizman Z, Shahak E, Gueron M (1991) Acute pancreatitis in children following envenomation by the yellow scorpion Tafuri WL, Maria TA, Freire-Maia L, Cunha-Melo JR (1974) Effect of the scorpion toxin on the granular vesicles in the Auerbach's plexus of the rat ileum. [10], found that the toxin of Tityus serrulatus scorpion is an agent of considerable efficacy in the induction of acute and pancreatitis … The development of systemic syndromes presumes a potential severity that can turn into a life-threatening emergency episodeThere are few cases of kidney injury due to scorpion stings reported in the literature.
The clinical presentation of envenomation is relatively similar, regardless of the species, and includes neurotoxic syndromes mediated by sympathetic and parasympathetic systemsMost scorpion envenomations only cause immediate local pain, however it can be accompanied by swelling, hyperemia, paresthesia and piloerection.
They suggest a direct action of the venom to pancreas. Biochemical profile of dogs experimentally envenomed with Tityus serrulatus scorpion venom.
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